Albumin to Globulin (A/G) Ratio Calculator
Calculate serum A/G ratio from total protein and albumin lab values to screen for liver cirrhosis, nephrotic syndrome, and myeloma.
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Common Searches & Natural Queries
What is the Albumin / Globulin?
Serum total protein consists primarily of albumin (produced solely by hepatocytes) and globulins (immunoglobulins produced by plasma B-cells, plus acute-phase transport proteins). The normal A/G ratio typically ranges between 1.1 and 2.5.
Mathematical Formula & Methodology
The mathematical model underlying this tool operates on the following verified equation:
Globulin = Total Protein - Albumin; A/G Ratio = Albumin / Globulin
Understanding the Parameters:
- Total Serum Protein (measured in g/dL) — Primary input variable.
- Serum Albumin (measured in g/dL) — Primary input variable.
How to Use This Calculator
Enter your total protein and serum albumin values from your Comprehensive Metabolic Panel (CMP). The tool computes globulin concentration and the resulting A/G ratio.
Worked Numerical Example
Total Protein = 7.2 g/dL, Albumin = 4.4 g/dL. Globulin = 7.2 - 4.4 = 2.8 g/dL. A/G Ratio = 4.4 / 2.8 = 1.57. This value lies right in the optimal reference bracket.
Key Considerations & Standards
A low A/G ratio (< 1.0) can signal underproduction of albumin (severe hepatic cirrhosis, malnutrition) or overproduction of globulins (multiple myeloma, autoimmune collagen vascular diseases).
Frequently Asked Questions
What does a high A/G ratio mean?
High A/G ratios (> 2.5) are less common and typically result from underproduction of antibodies (hypogammaglobulinemia) or acute dehydration hemoconcentration.
Can dietary protein intake rapidly alter the A/G ratio?
Albumin has a biological half-life of roughly 20 days; acute dietary changes will not immediately shift serum albumin levels unless chronic severe protein malnutrition is present.